A Versatile Natural Ingredient
Widely found in clove, black pepper, and rosemary essential oils, caryophyllene oxide meets EU Cosmetics Regulation (1223/2009) and IFRA standards, with a melting point of 62-63°C and levorotatory property of −70° in 20°C chloroform. Its woody-spicy aroma with warm sweet undertones serves as a "flavor backbone" in perfumery, offering 30%-50% longer fragrance retention and high-temperature stability (boiling point 279-301°C).
Notably, it exhibits potent biological activities: ≥0.8 mg/mL concentrations inhibit Klebsiella pneumoniae by 78.3%, enhance acetaminophen’s analgesic effect by 32% (reducing gastric irritation), and its derivatives show antiparasitic activity (9.3 μM IC₅₀ against Leishmania donovani). A 2024 study also highlighted its role in regulating temperature perception via giant panda cold receptors.
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