—— A Natural Compound with Bioactivity and Industrial Value Leads the Upgrade of Fragrance, Pharmaceutical, and Cosmetic Industries
(Special Report by [Correspondent's Name]) Recently, with the implementation of multiple research achievements and the expansion of industrial applications of caryophyllene oxide (CAS No.: 1139-30-6), this bicyclic sesquiterpene compound derived from essential oils of clove, black pepper, and other plants has set off an innovation boom in the fragrance, pharmaceutical, skincare, and daily chemical industries due to its unique chemical properties and diverse bioactivities. From the research on giant pandas' low-temperature adaptation mechanism to the technological breakthrough of transdermal absorption enhancers, its industrial value continues to be released, making it a key raw material for the green upgrading of related industries.
I. Natural Properties and Core Characteristics Lay the Industrial Foundation
Caryophyllene oxide has the molecular formula C15H24O, presenting as a white crystalline powder with a woody-spicy aroma and a melting point of 62-63°C. It complies with the EU Cosmetics Regulation (1223/2009), IFRA standards, and China's GB2760 Food Additive List. As a low-toxic flammable solid (oral LD50 in rats > 5000 mg/kg), it requires storage at 2-8°C in a dark and moisture-proof environment, making it an ideal alternative to some chemically synthesized raw materials. Global industrial sales have maintained steady growth from 2021 to 2025, with rising demand for high-purity products (≥98%) and supply dominated by leading enterprises.